
As the daughter of Duke Paul Frederick Augustus of Oldenburg (later Grand Duke of Oldenburg), she was born a duchess of Oldenburg, though that title was never used in Greece.
When she arrived in Greece in 1837, she at first won the hearts of the Greeks with her refreshing beauty.

As King Otto and his Bavarian advisers became more enmeshed in political struggles with Greek political forces, the Queen became more politically involved, also. She became the target of harsh attacks when she became involved in politics - and her image suffered further as she proved unable to provide an heir. She also remained a Protestant in an almost universally Orthodox country, throughout her husband's reign. Just over a year later, an uprising took place in Athens while the royal couple were on a visit to the Peloponnese. The Great Powers, who had supported Otto urged them not resist and Otto's reign was at an end. They left Greece aboard a British warship, with the Greek royal regalia that they had brought with them.

After the Queen became more politically involved, however, she became the target of harsh attacks — and her image suffered further as she proved unable to provide an heir. She and her husband were expelled from Greece in 1862, after an uprising. She spent the rest of her years in exile in Bavaria.