Mavi Boncuk Editor is J2 (M172)
See also : There is No Unique TURKISH DNA by Janet Crain
Mavi Boncuk |Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa
Can Alkan, Pinar Kavak, Mehmet Somel, Omer Gokcumen, Serkan Ugurlu, Ceren Saygi, Elif Dal, Kuyas Bugra, Tunga Güngör, S Cenk Sahinalp, Nesrin Özören and Cemalettin Bekpen
BMC Genomics201415:963
DOI: 10.1186/1471-2164-15-963© Alkan et al.; licensee BioMed Central Ltd. 2014
Received: 12 May 2014Accepted: 14 October 2014 Published: 7 November 2014
"... Our analyses show that genetic variation of the contemporary Turkish population is best described within the context of the Southern European/Mediterranean gene pool. However, we predict notable genetic sharing between Turkey’s population and East Asian and African populations. As expected from recent studies, rare and private genetic variation in Turkey has presumably more functional impact than variation shared among populations. We further identified SNPs that were previously associated with diseases that show allele frequency differentiation between Turkey and other Western European populations. Among these, those associated with pigmentation were at lower frequencies in Turkey than in Europe; meanwhile variants associated with total cholesterol levels were at higher levels in the former. Overall, our study improves the framework for population genomics studies in the region, and should incite novel genome-wide association studies in Turkey. Future studies using larger sample sizes will be able to elucidate population structure and history in more detail..." SOURCE
