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Compagnie Franco-Roumaine de Navigation Aérienne. CFRNA ("The French-Romanian Company for Air Transport"; French: Compagnie franco-roumaine de navigation aérienne; Romanian: Compania franceză - română pentru navigaţia aeriană), later CIDNA ( Compagnie internationale de navigation aérienne) was a French-Romanian airline, founded on January 1, 1920. CIDNA was one of the airlines of the merger which created Air France.[1]
The Compagnie Internationale de Navigation Aérienne (French) operated between Istanbul and Paris. Using French-built Potez aircraft, the company provided passenger, mail and cargo transportation, by air, from Paris to Bucharest, via Strasbourg, Prague, Vienna and Budapest. As such, CFRNA was the first operative transcontinental airline in the history of aviation.
The Societa Anonima Aero-Espresso Italiana also maintained a semi-weekly seaplane service between Büyükdere, Istanbul and Brindisi via Piraeus, Greece.

[1] Air France was formed on 7 October 1933 from a merger of Air Orient, Air Union, Compagnie Générale Aéropostale, Compagnie Internationale de Navigation Aérienne (CIDNA), and Société Générale de Transport Aérien (SGTA).